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Fig. 8 | Molecular Cancer

Fig. 8

From: TEAD4 modulated LncRNA MNX1-AS1 contributes to gastric cancer progression partly through suppressing BTG2 and activating BCL2

Fig. 8

Regulation relationship between MNX1-AS1 and miR-6785-5p. a Prediction of potential miRNAs targeting lncRNA MNX1-AS1 were analyzed using miRanda, pita, and RNAhybrid databases. b-d The luciferase reporter plasmid (pMIR-GLO-MNX1-AS1) was cotransfected into HEK-293 T cells with 5 miRNA-coding plasmids. The interacting activity between miRNAs and MNX1-AS1 was clarified using luciferase reporter assays. e, f MNX1-AS1 knockdown could obviously upregulate miR-6785-5p in GC cells, and MNX1-AS1 overexpression could significantly downregulate miR-6785-5p. g No significant difference in MNX1-AS1 expression after overexpression of miR-6785-5p in GC cells. h RNA levels in immunoprecipitates are presented as fold enrichment in AGO2 relative to IgG immunoprecipitates in SGC7901 and MGC803 cells

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Molecular Cancer

ISSN: 1476-4598