Fig. 4
From: m6A mRNA methylation regulates CTNNB1 to promote the proliferation of hepatoblastoma
m6A-Seq profiling of HB and identified CTNNB1 as a target of METTL3-mediated m6A modification. a Venn diagram of m6A modified genes in tumor and normal tissues. b The relationship between the number of genes and the peaks. c Top consensus motif identified DREME with m6A-seq in HB and normal tissues. d The normalized distribution of m6A peaks across the start codon, CDS, stop codon of mRNAs for normal and tumor m6A peaks. e Graphs of m6A peak distribution showing the proportion of total m6A peaks in the indicated regions in normal and tumor. f Comparison of the abundance of high level m6A peaks across the transcriptome of normal and tumor tissues. Genes with normal specific m6A peaks are highlighted in blue and genes with tumor-specific m6A peaks are highlighted in red. g Bar figure for the abundance of m6A modification percentage and gene expression. h Cumulative distribution curve for the gene expression changes between the tumor and normal tissues for up-regulated m6A methylation (Red) and down-regulated m6A methylation (Green). i The ratio of genes expression in normal (N) and tumor (T) tissues containing specific m6A peaks. Genes according to the peak position are divided into two groups (PeakStart and PeakStop). j KEGG pathway analysis of transcripts with increased m6A methylation and up-regulated mRNA expression in tumors against normal tissues. k Diagram of the Wnt/β-catenin pathway with genes affected by m6A marked by red. The diagram is based on KEGG annotations. l The m6A abundances on CTNNB1 mRNA transcripts in HB normal tissues and tumor tissues as detected by m6A-seq