Fig. 2
From: The emerging role of SPOP protein in tumorigenesis and cancer therapy
Cul-3 structure is illustrated. CRL3 contains three primary components including a Cul-3 protein as the scaffold protein, a RING-box protein (RBX1) that is essential for recruiting the E2 enzyme, and a Bric-a-brac-Tramtrack/Broad (BTB) protein; the BTB protein serves as both a substrate-recognition subunit (SRS) and the adaptor protein for substrate binding within this complex