Fig. 3From: The emerging role of SPOP protein in tumorigenesis and cancer therapySPOP structure is illustrated. The SPOP protein comprises an N-terminal MATH domain, an internal BTB/POZ domain, a BACK domain, a 3-box domain and a C-terminal nuclear localization sequence (NLS). The MATH domain of SPOP selectively recognizes and recruits substrates and includes key amino acid residues such as Y87, F102, Y123, W131 and F133Back to article page