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Fig. 6 | Molecular Cancer

Fig. 6

From: Circular RNA CRIM1 functions as a ceRNA to promote nasopharyngeal carcinoma metastasis and docetaxel chemoresistance through upregulating FOXQ1

Fig. 6

CircCRIM1 is associated with unfavorable prognosis and docetaxel-based IC resistance in patients with NPC. a-c Kaplan-Meier analysis of overall survival (OS, a), disease-free survival (DFS, b) and distant metastasis-free survival (DMFS, c) in NPC patients with low and high circCRIM1 expression. d-f OS (d), DFS (e) and DMFS (f) in NPC patients with low risk (low circCRIM1 expression and early N stage), intermediate risk (high circCRIM1 expression or advanced N stage) and high risk (high circCRIM1 expression and advanced N stage) according to the prognostic prediction model. g DMFS in low risk patients receiving IC with or without docetaxel. P values were determined using the log-rank test. h Hypothetical model for circCRIM1 function in NPC. CircCRIM1 acts as a sponge of miR-422a to promote NPC metastasis and docetaxel chemoresistance by relieving FOXQ1 expression

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Molecular Cancer

ISSN: 1476-4598