Fig. 9

Blocking NF-κB signaling pathway reverses PLACT1-induced PDAC progression in vivo.a Representative images of subcutaneous xenografts and IHC for Ki-67. PBS or JSH-23 treatments began 1 week after inoculation (n = 10). b Histogram analysis of luminescence for subcutaneous xenografts in indicated group (n = 10). c Tumor volumes were measured in the indicated groups (n = 10). d Histogram analysis of Ki-67 positive cells in indicated group (n = 10). e Survival analysis for tumor bearing mice in indicated group (n = 10). f Model of the role of PLACT1 forming a positive feedback loop with IκBα/E2F1 in PDAC. Statistical significance was evaluated by using ANOVA, followed by Dunnett’s tests for multiple comparison. The error bars represent standard deviations of three independent experiments. *p < 0.05 and **p < 0.01