Table 1 Patient’s demographics and tumor characteristics and association of ALKBH5 levels with clinicopathological features
Characteristics | No. of patients, N = 60 (%) | P value |
|---|---|---|
Patients Parameter | ||
Age (years) | 0.871 | |
Average [range] | 53 [30–81] | |
< 53 | 20 (33.3) | |
≥ 53 | 40 (66.7) | |
Gender | 0.714 | |
Male | 32 (53.3) | |
Female | 28 (46.7) | |
Smoking history | ||
Smoker | 35 (58.3) | 0.12 |
Non-smoker | 25 (41.7) | |
Tumor Characteristics | ||
Tumor size (cm) | 0.009** | |
< 4 | 10 (16.7) | |
≥ 4 | 50 (83.3) | |
Differentiation | 0.044* | |
Poor | 41 (68.3) | |
Well-moderate | 19 (31.7) | |
Lymph node metastasis | 0.014* | |
N- | 9 (15.0) | |
N+ | 51 (85.0) | |
Distant metastasis | 0.008** | |
M- | 8 (13.3) | |
M+ | 52 (86.7) | |
Expression of ALKBH5 | ||
Protein level | ||
high | 2 (3.3) | 0.086 |
median | 8 (13.3) | 0.078 |
low | 50 (83.4) | 0.002** |
mRNA level | ||
high | 3 (5.0) | 0.074 |
median | 9 (15.0) | 0.063 |
low | 48 (80.0) | 0.001** |
Expression of YAP | ||
Protein level | ||
high | 46 (76.6) | 0.008** |
median | 9 (15.5) | 0.062 |
low | 5 (7.9) | 0.865 |
mRNA level | ||
high | 48 (80.0) | 0.005** |
median | 8 (13.3) | 0.084 |
low | 4 (6.7) | 0.754 |