Fig. 6
From: CircMUC16 promotes autophagy of epithelial ovarian cancer via interaction with ATG13 and miR-199a
RUNX1 promoted the expression of circMUC16. a The putative binding sites between circMUC16 and RUNX1. b SKOV3 cells co-transfected with MUC16 reporter gene plasmid and NC (negative control), RUNX1 siRNA, PCMV5-RUNX1 or PCMV5-NC (empty vector). After 48 h, luciferase activity was measured. c SKOV3 cells transfected with NC (negative control), RUNX1 siRNA, PCMV5-RUNX1 or PCMV5-NC (empty vector). After 48 h, the linear mRNAs of MUC16 and circMUC16 were detected by qPCR. d Overall survival was analyzed in ovarian cancer patients based on TCGA data. All experiments were repeated three times. Error bars represent the standard error. The symbols * and ** indicate p < 0.05 and 0.01, respectively