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Fig. 1 | Molecular Cancer

Fig. 1

From: CCL2-CCR2 axis recruits tumor associated macrophages to induce immune evasion through PD-1 signaling in esophageal carcinogenesis

Fig. 1

CCL2 expression correlates with TAMs accumulation, cancer progression and poor prognosis in human ESCC. a Representative IHC staining indicates escalating expression of CCL2 with histopathologic progression. b Expression of CCL2 in different pathologic grades of cohort I patients including normal mucosa (10 cases), dysplasia (22 cases), and ESCC (58 cases). c Expression of CCL2 in para-cancer and cancer tissues of cohort II patients (n = 100). d Representative IHC staining indicates correlated expression of CCL2 and CD68 in ESCC. e CCL2 expression is correlated with accumulation of CD68+ TAMs. f and g High-expression of CCL2 (f) and CD68 (g) predicts reduced overall survival of ESCC patients

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Molecular Cancer

ISSN: 1476-4598