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Fig. 7 | Molecular Cancer

Fig. 7

From: CCL2-CCR2 axis recruits tumor associated macrophages to induce immune evasion through PD-1 signaling in esophageal carcinogenesis

Fig. 7

Blockade of TAMs M2-polarization via macrophage-specific PPARG deletion reduces PD-L2 expression and inhibits tumorigenesis. a Macrophage-specific gene knockout of PPARG in mouse reduces tumor growth in ESCC mouse model (n = 6). b Flow cytometry analysis shows deficiency of PPARG in macrophage suppresses M2-polarization and PD-L2 expression in TAMs and increases CD8+ CTLs in forestomach tumors (n = 6). c Schematic figure indicates esophageal carcinogenesis can be blocked by targeting TAMs infiltration via CCL2/CCR2 signaling (Target I) and M2 polarization via PPARG activation (Target II)

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Molecular Cancer

ISSN: 1476-4598