Fig. 4
From: Metabolism of pancreatic cancer: paving the way to better anticancer strategies
Gemcitabine resistance and metabolism. Gemcitabine and some intrinsic characteristics of pancreatic cancer cells produce chemoresistance. Ovals are biological substances, rectangles are processes, and hexagons are statuses. Red names indicate corresponding inhibitors. Arrows represent positive regulations, and lines with blunt ends represent negative regulations. CR, chemoresistance; EMT, epithelial-mesenchymal transition; FBP1, fructose-1,6-bisphosphatase 1; IDH1, isocitrate dehydrogenase 1; LAT2, L-type amino acid transporter 2; noPPP, nonoxidative pentose phosphate pathway; RRM2, ribonucleotide reductase subunit-M2