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Fig. 7 | Molecular Cancer

Fig. 7

From: A novel protein encoded by circFNDC3B inhibits tumor progression and EMT through regulating Snail in colon cancer

Fig. 7

circFNDC3B-218aa promotes the tumor-suppressive effect of FBP1 in CC via inhibiting Snail. a The expression of levels of FBP1 and E-cadherin were inhibited by Snail, but this effect was restored by circFNDC3B-218aa presented in Western blot analysis. b The relative protein expression of Snail, FBP1, E-cadherin and vimentin as detected by Western blot analysis. c The invasion abilities enhanced by Snail were restored after co-transfection with circFNDC3B-218aa using transwell assay. d The invasion abilities enhanced by downregulated FBP1 were restored after co-transfection with circFNDC3B-218aa using transwell assay. e The migration abilities enhanced by Snail were restored after co-transfection with circFNDC3B-218aa using wound-healing assay. f The migration abilities enhanced by downregulated FBP1 were restored after co-transfection with circFNDC3B-218aa using wound-healing assay. g The glucose uptake, h pyruvate production, i lactate production, j ATP status in HCT116 and DLD1 cell lines. **P < 0.01, ***P < 0.001

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Molecular Cancer

ISSN: 1476-4598