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Fig. 4 | Molecular Cancer

Fig. 4

From: CircLONP2 enhances colorectal carcinoma invasion and metastasis through modulating the maturation and exosomal dissemination of microRNA-17

Fig. 4

circLONP2 is essential for CRC metastasis. a, b Overexpression of circLONP2 significantly enhanced the migration and invasion ability of CRC cells. c, d Knockdown of circLONP2 by ASO significantly suppressed the migration and invasion ability of CRC cells. e, f In vivo tail vein injection model confirmed that overexpression or knockdown of circLONP2 could significantly promote or attenuate CRC cells metastasize to lung, respectively. All detection of circLONP2 by RT-qPCR was normalized to GAPDH. All experiments were repeated for three times, data were shown as mean ± SD, * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001 in Mann-Whitney U test (a, c, e, f), or independent Student’s t test (b, d)

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Molecular Cancer

ISSN: 1476-4598