microRNAs identified in prostate cancer: Correlative studies on response to ionizing radiation

Table 2 exosomal miRNAs in radiotherapy response in prostate cancer

miRNA	Biomarkers	Biofluids	Main results	Cohorts	References	Targets
let-7a-5p	Efficacy of RT	Serum exosomes	Upregulated in exosomes of high-risk PCa patients after RT compared to intermediate-risk PCa patients	11 PCa patients (6 intermediate-risks, 5 high-risk disease)	[146]	-
miR-21	Diagnostic/ efficacy of RT	Serum exosomes		11 PCa patients (6 intermediate-risks, 5 high-risk disease)	[146]	PTEN [147], MARCKS [148], ANP32A, SMARCA4 [149]
miR-200c-3p	Efficacy of CIRT	Serum exosomes	Upregulation in exosomes is associated with a good response to CIRT	8 PCa patients (3 intermediate risk, 2 high risk, 3 very high risk)	[150]	ZEB1, ZEB2 [128]
miR-323-3p						p73 [151], AdipoR1 [152]
miR-379-5p						-
miR-409-3p						PHC3, RSU1,TUSC1 [153]
miR-411-5p						-
miR-493-5p						c-Met, CREB1, EGFR [154]
miR-494-3p						CXCR4 [155]
miR-543						RKIP [156]
miR-654-3p						AR [74]

RT radiotherapy, CIRT carbon ion radiotherapy, PCa prostate cancer, PTEN phosphatase and TENsin homolog, MARCKS myristoylated alanine-rich protein kinase c substrate, ANP32A acid nuclear phosphoprotein 32 family member A, SMARCA4 SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 4, AdipoR1 Adiponectin receptor 1, PHC3 polyhomeotic homolog 3, RSU1 Ras suppressor protein 1, TUSC1 tumor suppressor candidate 1, CREB1 CAMP responsive element binding protein 1, EGFR epidermal growth factor, CXCR4 CXC chemokine receptor 4, RKIP Raf kinase inhibitor protein, AR androgen receptor

ISSN: 1476-4598