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Fig. 3 | Molecular Cancer

Fig. 3

From: Linear and circular PVT1 in hematological malignancies and immune response: two faces of the same coin

Fig. 3

Model of PVT1 and circPVT1 pro-tumorigentic functions in hematological malignancies. PVT1 and circ-RNA act as a miRNA sponge and regulate the energy metabolism, protein stability, cell cycle progression through a variety of pathways, thus promoting cell proliferation, immune suppression and inhibiting cell death (green represents induction, red indicates suppression, dashed line shows indirect and not specified mechanisms; ROS: reactive oxygen species; RBPs: RNA-binding proteins, including EIF4A3, U2AF65, AGO2, AUF1, DGCR8, FUS, HNRNPC, PTB, TAF15, TDP43, TIA1, TIAL1, LIN28A)

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Molecular Cancer

ISSN: 1476-4598