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Fig. 8 | Molecular Cancer

Fig. 8

From: Long noncoding RNA ZFAS1 promoting small nucleolar RNA-mediated 2′-O-methylation via NOP58 recruitment in colorectal cancer

Fig. 8

The schematic diagram illustrated that ZFAS1 targeting recruitment NOP58 regulated rRNA 2′-O-methylation mediated protein translation to mediate colorectal cell proliferation. In normal intestinal epithelial cells, ZFAS1, NOP58 and snoRNAs are expressed normally, as well as the level of the rRNA 2′-O-methylation and translation. In CRCs cells and tissues, ZFAS1 is overexpressed, and its binding protein NOP58, which is one of the snoRNPs, is also overexpressed. ZFAS1 increases the snoRNPs formed by the synergistic recruitment of snoRNAs in combination with NOP58, especially SNORD12C and SNORD78.This results in an increase in the level of rRNAs 2′-O-Me modification, which ultimately leads to changes in translational activity and precision of downstream target genes, thereby mediating colorectal cancer proliferation

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