Fig. 1

Expression profiles of circRNA in GC tissues and cell lines. a. Schematic illustration exhibiting overlap of circRNAs in RNA-seq (right) and circBase (left). b. Number of diverse length distributions of circRNAs. c. Composition of the detected circRNAs in terms of genomic origin. d. Circos plot displayed the distribution and expression of circRNAs on human chromosomes. The outermost layer was a chromosome map of the human genome. The inner circles from outside to inside corresponded to distribution and expression of detected circRNAs on the chromosomes, distribution and expression of significantly expressed circRNAs and predicted miRNAs sponged by significantly expressed circRNAs, respectively. e. A cluster heat map presented the significantly dysregulated circRNAs in GC tissues relative to matched adjacent normal tissues. The red and blue strips represented high and low expression, respectively. f. Relative expression of circCCDC9 in GC tissues and matched adjacent normal tissues was detected by qRT-PCR (n = 48). g. Relative expression of circCCDC9 in cell lines was determined by qRT-PCR. Data were showed as mean ± SD, *P < 0.05, **P < 0.01, ***P < 0.001