Exosomal circSHKBP1 promotes gastric cancer progression via regulating the miR-582-3p/HUR/VEGF axis and suppressing HSP90 degradation

Table 1 Relationship between circSHKBP1 expression and clinicopathologic factors of patients with gastric cancer

Parameter	No. of patients	circSHKBP1(low)	circSHKBP1(high)	P value (* P <0.05)
Sex
Male	108	51	57	0.283
Female	44	25	19
Age (year)				0.224
< 60	49	28	21
≥ 60	103	48	55
Tumor size (cm)				0.033*
< 5	65	39	26
≥ 5	87	37	50
Tumor site				0.320
Upper	16	7	9
Middle	58	32	26
Lower	64	33	31
Diffuse	14	4	10
Differentiation grade				0.001*
Well-moderate	60	40	20
Poor-undifferentiation	92	36	56
Lauren classification				0.037*
Intestinal	72	41	31
Diffuse	64	25	39
Mixed	16	10	6
T stage				0.052
T1-T2	34	22	12
T3-T4	118	54	64
Lymph node status				0.194
Negative	39	23	16
Positive	113	53	60
Distant metastasis				0.513
M0	142	72	70
M1	10	4	6
TNM stage				0.027*
I-II	53	33	20
III-IV	99	43	56
Vascular invasion				0.036*
Negative	104	58	46
Positive	48	18	30
Lymphatic invasion				0.827
Negative	127	64	63
Positive	25	12	13
Nervous invasion				1.000
Negative	138	69	69
Positive	14	7	7

The TNM Staging System is based on the tumor (T), the extent of spread to the lymph nodes (N), and the presence of metastasis (M)

ISSN: 1476-4598