Skip to main content
Fig. 6 | Molecular Cancer

Fig. 6

From: Cancer cell-derived exosomal circUHRF1 induces natural killer cell exhaustion and may cause resistance to anti-PD1 therapy in hepatocellular carcinoma

Fig. 6

CircUHRF1 induces immune evasion in an NK cell-dependent manner. a CircUHRF1 expression in PLC/PRF/5 cells was modified by lentiviral vector transfection. b CircUHRF1 expression in HCC cell-derived exosomes was increased in the PLC/PRF/5-circUHRF1 group. c The effects of circUHRF1 overexpression on lung metastasis were investigated in vivo (n = 6 mice for each group). d CircUHRF1 expression in mouse serum-derived exosomes was increased in PLC/PRF/5-circUHRF1 cells. e NKG2D-positive cells in the PLC/PRF/5-circUHRF1 or PLC/PRF/5-mock cell-derived tissues were analyzed by IHC. The data are represented as the mean ± SD; n = 3, *P < 0.05, **P < 0.01, ***P < 0.001

Back to article page

Molecular Cancer

ISSN: 1476-4598