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Table 3 Univariate and multivariate analyses of factors associated with cumulative recurrence

From: Cancer cell-derived exosomal circUHRF1 induces natural killer cell exhaustion and may cause resistance to anti-PD1 therapy in hepatocellular carcinoma

  Cumulative Recurrence
  Multivariate
Factors Univariate, P HR 95% CI P value
Sex (Female vs. Male) 0.527    NA
Age (years) (≤50 vs. > 50) 0.393    NA
HBsAg (Positive vs. Negative) 0.266    NA
HCVAb (Positive vs. Negative) 0.494    NA
Liver cirrhosis (Yes vs. No) 0.802    NA
Serum AFP, ng/mL (≤20 vs. > 20) 0.472    NA
Serum ALT, U/L (≤75 vs. > 75) 0.615    NA
Tumor size (diameter, cm) (> 5 vs ≤ 5) 0.066    NA
NK cell proportion in blood (≤ 8% vs. >  8%) 0.149    NA
TNM (III/IV vs I/II.) 0.277    NA
CircUHRF1 expression (High vs. Low) 0.004 1.762 1.172–2.428 0.019
  1. NA not adopted; AFP alpha-fetoprotein; HBsAg hepatitis B surface antigen; 95%CI 95% confidence interval; BCLC Barcelona-Clinic Liver Cancer, HR hazard ratio; Cox proportional hazards regression model