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Table 3 Univariate and multivariate analyses of factors associated with cumulative recurrence

From: Cancer cell-derived exosomal circUHRF1 induces natural killer cell exhaustion and may cause resistance to anti-PD1 therapy in hepatocellular carcinoma

 

Cumulative Recurrence

 

Multivariate

Factors

Univariate, P

HR

95% CI

P value

Sex (Female vs. Male)

0.527

  

NA

Age (years) (≤50 vs. > 50)

0.393

  

NA

HBsAg (Positive vs. Negative)

0.266

  

NA

HCVAb (Positive vs. Negative)

0.494

  

NA

Liver cirrhosis (Yes vs. No)

0.802

  

NA

Serum AFP, ng/mL (≤20 vs. > 20)

0.472

  

NA

Serum ALT, U/L (≤75 vs. > 75)

0.615

  

NA

Tumor size (diameter, cm) (> 5 vs ≤ 5)

0.066

  

NA

NK cell proportion in blood (≤ 8% vs. >  8%)

0.149

  

NA

TNM (III/IV vs I/II.)

0.277

  

NA

CircUHRF1 expression (High vs. Low)

0.004

1.762

1.172–2.428

0.019

  1. NA not adopted; AFP alpha-fetoprotein; HBsAg hepatitis B surface antigen; 95%CI 95% confidence interval; BCLC Barcelona-Clinic Liver Cancer, HR hazard ratio; Cox proportional hazards regression model