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Fig. 4 | Molecular Cancer

Fig. 4

From: Bmi-1-induced miR-27a and miR-155 promote tumor metastasis and chemoresistance by targeting RKIP in gastric cancer

Fig. 4

Bmi-1 regulates cell migration, invasion, proliferation and chemosensitivity via miR-155 and miR-27a in vitro. a Bmi-1 knockdown inhibited cell migration and invasion, which were enhanced by miR-155 or miR-27a (100 × magnification). b miR-155 or miR-27a improved cell proliferation, which was inhibited by Bmi-1 suppression. c Colony formation assays either in soft agar or on plates demonstrated that the shBmi-1 group generated fewer colonies than any other group, and the effect could be reversed by miR-155 or miR-27a. d MTS was performed to evaluate the IC50 values of cells upon different treatments. The inhibition of Bmi-1 enhanced chemosensitivity, while miR-155 and miR-27a increased the IC50. *P < 0.05 vs. shcon, #P < 0.05 vs. NC mimic

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Molecular Cancer

ISSN: 1476-4598