Fig. 2

CircRNAs self-circularize mechanisms. a. MiR-671 binds to a highly complementary miRNA binding site in ciRS-7, thereby triggering the cleavage of AGO2. b. When cells are stimulated or infected by viruses, RNase L activates and degrades circRNAs molecules. c. CircRNAs with m⁶A sequences have two ways of self-renewing. d. The GW182 gene in drosophila cells and the human homologous genes TNRC6A, TNRC6B, and TNRC6C mediate the apoptosis of circRNAs. e. The regulation of UPF1 or G3BP1 can degrade CircRNAs with complex structures. f. CircRNAs are removed from the cytoplasm by exosomes or direct release into the extracellular space