CircRNAs: biogenesis, functions, and role in drug-resistant Tumours

Ma, Shuo; Kong, Shan; Wang, Feng; Ju, Shaoqing

doi:10.1186/s12943-020-01231-4

Molecular Cancer

Table 1 The mechanisms and biological functions of main circRNAs

From: CircRNAs: biogenesis, functions, and role in drug-resistant Tumours

circRNA	Mechanisms	Location	Functions	Refs
CIRS-7(CDR1as)	Sponges miR-7	cytoplasm	Regulates the nervous system and promotes drug resistance	[17, 105, 157, 158]
circ-Sry	Sponges miR-138	cytoplasm	Relates to gender determination	[17]
circ-SOX4	Sponges miR-1270 and up-regulated PLAGL2	cytoplasm	Promotes the proliferation, invasion and migration of LUAD cells	[74]
circTCF25	Sponges miR-103a-3p and miR-107 increased the expression of CDK6	cytoplasm	Promotes the proliferation of bladder cancer cells	[75]
circ-TFF1	miR-326/TFF1 axis	cytoplasm	Carcinogenesis in breast cancer	[76]
circPTPRA	Sponges miR-96-5p	cytoplasm	Inhibition of EMT in NSCLC cells	[78]
circRIP2	Sponges miR-1305, activated Tgf 2/ Smad3 pathway	cytoplasm	EMT is induced to promote the proliferation, invasion and migration of bladder cancer	[79]
circAMOTL1L	Sponges miR-193a-5p	cytoplasm	Promotes EMT in prostate cancer cells	[80]
CircCSNK1G3	Sponges miR-181b/d	cytoplasm	Stabilize miRNAs and promote cell proliferation	[49]
CircMb1	Combines with the MBL	cytoplasm	Relates to neuromodulation	[1]
Ci-ankrd52	Binds to RNA Pol II	nucleus	Cis-regulation promotes transcription of ANKRD52	[32]
circIIF3J	Interacts with U1 snRNP and RNA Pol II	nucleus	Enhances the transcription of parental genes	[81]
circPAIP2	Interacts with U1 snRNP and RNA Pol II	nucleus	Enhances the transcription of parental genes	[81]
circMYBL2	Binds to the protein PTBP1	cytoplasm	Promotes the development of flt3-itd mutant white blood	[82]
circAmotl1	Binds PDK1 and AKT1	cytoplasm	Protein scaffolds promote phosphorylation and promote cardiac protective nuclear translocation	[20]
circFOXO3	Binds to the complex of ID-1, CDK2-p21 and p53-MDM2	cytoplasm	Affects cell senescence, cell cycle and apoptosis	[83, 84]
circZNF609	Translation template	cytoplasm	Specifically controls the proliferation of myoblasts	[23]
circSHPRH	Translation template	cytoplasm	Inhibits cell proliferation and tumor suppressors	[96]
circ-LINCPINT	Translation template	cytoplasm	Inhibits cell proliferation and tumor suppressors	[97]
circFBXW7	Translation template	cytoplasm	Inhibits the proliferation of cancer cells and the acceleration of the cell cycle	[98]
circPPP1R12A	Translation template	cytoplasm	Inhibits cell proliferation and tumor suppressors	[21]

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ISSN: 1476-4598

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