Fig. 3
From: Comprehensive elaboration of the cGAS-STING signaling axis in cancer development and immunotherapy
The protumor role of the cGAS-STING signaling pathway. A Chronic activation of STING creates an immunosuppressive tumor microenvironment. Continuous STING activation in turn impedes the original antitumor immunity by increasing the infiltration of MDSCs, Tregs and expression of PD-L1, IDO and CCR2, while decreasing the infiltration of NK cells, DCs and T cells. B The function of the STING signaling in tumor metastasis. B-1 delineates the cell autonomous pro-metastasis effect, and B-2, B-3 depict the cell nonautonomous pro-metastasis effect