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Fig. 3 | Molecular Cancer

Fig. 3

From: Characterization of a novel HDAC/RXR/HtrA1 signaling axis as a novel target to overcome cisplatin resistance in human non-small cell lung cancer

Fig. 3

The relationship between HDAC, RXR and HtrA1 in NSCLC cases and their clinical significance in NSCLC. a. Representative sections of NSCLC tumor tissues from two patients treated with platinum. The expression of HDAC1, RXRα and HtrA1 was detected using immunohistochemistry. Patient 1# was HDAC1 low/RXRα high/HtrA1 high. Patient 2# was HDAC1 high/RXRα low/HtrA1 low. b. Statistical analysis of the expression patterns of HDAC1, RXRα and HtrA1 in tissue specimens from 101 NSCLC patients treated with platinum. c and d. Correlation of the expression of HtrA1 protein with c the treatment response and d the overall survival. CR, complete response; PR, partial response; SD, stable disease; PD, progressive disease

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Molecular Cancer

ISSN: 1476-4598