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Fig. 4 | Molecular Cancer

Fig. 4

From: The role of m6A, m5C and Ψ RNA modifications in cancer: Novel therapeutic opportunities

Fig. 4

Simplified structure of a tRNA and all known Ψ and m5C events in humans. Ψ modification is shaded in blue and m5C in purple. The table on the right indicates the position and modification in tRNA, the human enzyme that has been identified to catalyse this modification, the sub-cellular localization of tRNAs containing the modification. m5C, 5-methylcytosine; f5C, 5-formylcytosine Ψ, pseudouridine; Ψ derivates: Ψm, 2ʹ-O-methylpseudouridine and m1Ψ, 1-methylpseudouridine. Proteins: PUS, pseudouridine synthase; RPUSD, RNA pseudouridine synthase domain-containing protein; NSUN, NOL1/NOP2/SUN domain family member; DNMT2, DNA methyltransferase 2. f5C* is formed from m5C by ALKBH1 (Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 1) in mitochondrial tRNAs. Ψ derivates are formed from Ψ by methyltransferases

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