Long noncoding RNAs: functions and mechanisms in colon cancer

Chen, Sian; Shen, Xian

doi:10.1186/s12943-020-01287-2

Molecular Cancer

Table 1 Representative lncRNAs and related signaling pathways in colon cancer

From: Long noncoding RNAs: functions and mechanisms in colon cancer

lncRNA	Expression	Functions	Downstream targets	References
ATB	↑	Enhances invasion, induces EMT	E-cadherin, ZO-1, ZEB1, N-cadherin	[25]
BC200	↑	Increases proliferation, invasion, EMT, inhibits apoptosis, regulates cell cycle	STAT3, β-catenin	[24]
B3GALT5-AS1	↓	Inhibits proliferation, promotes migration, invasion, induces EMT	miR-203, ZEB2, Snail	[26]
CASC15	↑	Promotes proliferation, migration, invasion	miR-4310, LGR5, Wnt/β-catenin	[27]
CASC19	↑	Increases migration	N/A	[28]
CCAT1	↑	Promotes proliferation, invasion, drug resistance	c-Myc	[29,30,31]
CCAT2	↑	Enhances growth, metastasis	miR-145, WNT	[32, 33]
CYTOR	↑	Promotes migration, invasion, EMT	β-catenin/TCF complex,	[34, 35]
DACOR1	↓	Inhibits proliferation, increases DNA methylation	Cystathionine β-synthase	[36, 37]
DMTF1v4	↑	Increases proliferation, migration, inhibits apoptosis	p-ERK, p-JNK, p-p38	[38]
ENST00000455974	↑	Increases proliferation, migration	JAG2	[39]
FAL1	↑	Enhances proliferation, invasion, Inhibits apoptosis	STAT3, TGF-β1, Bcl-2, p65, PCNA	[40]
FAM83H-AS1	↑	Promotes tumorigenesis	TGF-β signaling	[41]
FER1L4	↓	Inhibits proliferation, migration, invasion	miR-106a-5p	[42]
GSEC	↑	Promotes migration	DHX36	[43]
HNF1A-AS1	↑	Enhances proliferation, migration, invasion	miR-34a/p53	[44]
HOTAIR	↑	Increases migration, invasion	E-cadherin, vimentin, MMP-9	[45,46,47]
HULC	↑	Promotes proliferation, migration, invasion	miR-613, RTKN, vimentin, N-cadherin, E-cadherin	[48]
H19	↑	Enhances invasion, migration, drug resistance	miR138, HMGA1, miR-675-5p	[49, 50]
Linc00973	/	Involves in drug resistance	N/A	[51]
Linc01106	↑	Confers proliferation, migration, stemness	miR-449b-5p, Gli	[52]
Linc01234	↑	Promotes proliferation	miR-642a-5p, SHMT2	[53]
Linc01567	↑	Promotes proliferation, invasion, migration	miR-93	[54]
Linc00261	↓	Inhibits proliferation, invasion, migration, drug resistance, induces apoptosis.	β-catenin, Wnt pathway	[55]
Linc00657	↓	Inhibits proliferation, invasion, induces apoptosis	CAPN7, PI3K/Akt	[56]
Linc01082	↓	Represses proliferation, migration, Invasion	/	[21]
Linc01578	↑	Enhances metastasis	NF-κB, YY1	[57]
Linc02418	↑	Promotes growth, mobility, invasion, inhibits apoptosis	miR-34b-5p, Bcl-2	[58]
Lnc34a	↑	Enhances proliferation, stem cells	Dnmt3a, PHB2,HDAC1	[59]
Loc285194	↓	Inhibits proliferation	miR-211	[60]
Loc441461	↑	Increases growth, motility, inhibits apoptosis	PhoA, ROCK	[61]
LincDUSP	↑	Promotes proliferation, stem cells, modulates DNA damage response and cell cycle, inhibits apoptosis	ATR, p53, E2F, c-Myc	[19]
MALAT1	↑	Enhances proliferation, invasion, migration	miR-129-5p, HMGB1, miR-663a	[62,63,64]
MYU	↑	Increases proliferation, controls cell cycle	hnRNP-K, CDK6	[65]
PCAT6	↑	Promotes proliferation, induces apoptosis	EZH2, H3K4me3	[22]
Pint	↓	Inhibits proliferation	PRC2	[66]
PVT1	↑	Promotes proliferation, migration, invasion	miR-26b, miR-30d-5p/RUNX2	[67, 68]
RBM5-AS1	/	Promotes proliferation, maintains stem cells	WNT, β-catenin	[69]
ROR	↑	Enhances proliferation, migration, invasion	miR-145	[70]
RP11-619 L19.2	↑	Enhances proliferation, migration, invasion, EMT	miR-1271-5p, CD164	[71]
SnaR	↑	Promotes drug resistance	N/A	[72]
SBDSP1	↑	Promotes proliferation, migration, invasion, regulates cell cycle,	p21, cyclin D1, Akt, ERK1/2, STAT3	[73, 74]
SNHG1	↑	Increases proliferation, invasion, migration, inhibits apoptosis	Wnt/β-catenin, c-Myc, cyclin D	[75]
SNHG7	↑	Increases proliferation, inhibits apoptosis	miR-193b, K-ras/ERK/cyclinD1	[76]
SNHG15	↑	Enhances proliferation, migration	Slug	[77]
SNHG17	↑	Elevates proliferation, migration, invasion	miR-375, CBX3	[78]
TUG1	↑	Promotes proliferation, migration, invasion, EMT, inhibits apoptosis,	miR-26a-5p, MMP-14, VEGF, MAPK, Hsp27	[23, 79]
UPAT	↑	Promotes survival	UHRF1	[80]
USP2-AS1	↑	Enhances proliferation, metastasis	Phosph-YAP	[81]
XIST	↑	Promotes proliferation	miR-34a, Wnt, β-catenin cyclin D1, c-Myc, MMP-7	[82]
ZEB1-AS1	↑	Enhances proliferation, migration, invasion	miR-455-3p, PAK2	[20]
ZFAS1	↑	Increases proliferation, invasion, EMT, inhibits apoptosis,	ZEB1, E-cadherin, ZO-1, vimentin, N-cadherin	[83]

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