Fig. 1
From: Taking the Myc out of cancer: toward therapeutic strategies to directly inhibit c-Myc
The structure and interaction partners of c-Myc. a Crystal structure of the c-Myc/Max dimer bound to E-box DNA (PDB ID 1NKP) [2]. b Scheme showing activating and repressing interaction partners, represented by double headed arrows, within the Myc/Max/Mxd network [3, 4]. c Different regions of c-Myc protein, including the MYC boxes (0, I, II, IIIa, IIIb, IV), Nuclear Localization Sequence (NLS) and bHLHZip domain along with the binding sites of its key interaction partners [5,6,7,8,9,10]