Proposed mechanisms of Omomyc. Studies have suggested that: 1. Omomyc (Orange) homodimer blocks c-Myc/Max dimer from binding to E-box DNA (Red). 2. Omomyc binds to Max (Green), sequestering Max from c-Myc (Blue) and 3. In the presence of Omomyc, c-Myc levels are reduced due to proteasomal degradation, a process potentially tiggered by 2 [49, 105].