Skip to main content
Fig. 2 | Molecular Cancer

Fig. 2

From: Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy

Fig. 2

Complex network in TME orchestrating EMT. TME consists of TAMs, T cells, MDSCs, and CAFs. Through secretion of different cytokines and chemokines, it causes downregulation of epithelial marker, E-cadherin and upregulation of mesenchymal markers such as N-cadherin, vimentin, snail and ZEB1. In TME, these cells also upregulate cell signaling pathways such as STAT3, NF-kB and β-catenin, which all contribute to cell survival

Back to article page

Molecular Cancer

ISSN: 1476-4598