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Fig. 5 | Molecular Cancer

Fig. 5

From: Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy

Fig. 5

Tumor evasion from immune surveillance mediated by cytokines/chemokines in the TME. Cancer cells secrete several chemokines and cytokines that inhibit NK cells, DCs, and T cell functions and recruit TAMs. Tumor cells also induce MDSCs and Treg T cells that can further inhibit T cell function. TAMs and tumor cells both express PD-L1/2 to inhibit T-cell activation via the PD-1 receptor. Altogether, these cells suppress antitumor immunity while also promoting tumor growth and progression by various mechnisms

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Molecular Cancer

ISSN: 1476-4598