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Fig. 1 | Molecular Cancer

Fig. 1

From: Translation and functional roles of circular RNAs in human cancer

Fig. 1

Cap-independent translation of circRNAs in eukaryotic cell. The circRNA can be divided into three different types: exonic (EcRNA), intronic (CiRNA) and exon-intron (EIcRNA) . CiRNAs and EIcRNAs are likely sequestered in the nucleus, while EcRNAs are mostly exported into cytoplasm. Internal Ribosome Entry site (IRES)- and N6-methyladenosines (m6A)-mediated cap-independent translation initiation are potential mechanisms for circRNA translation. These structures allow the internal recruitment of the 40S ribosomal subunit

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Molecular Cancer

ISSN: 1476-4598