Fig. 5
From: The inflammatory kinase IKKα phosphorylates and stabilizes c-Myc and enhances its activity
Correlation of c-Myc and IKKα expression in mouse prostates and human cancers. a Representative immunofluorescence staining of IKKα and c-Myc in mouse prostate tissues of wild-type and Hi-MYC mice. White arrows indicate regions of coincident high c-Myc/high IKKα levels. b c-Myc levels plotted against IKKα expression for wild-type and Hi-MYC prostate sections. Each dot represents a small region of the prostate epithelium normalized to the nuclear stain (DAPI). Note the different y-axis scale. c Pearson’s correlation between the expression values in Transcript Per Million of IKKα (CHUK) and c-Myc (MYC) in several types of human cancers from the TCGA dataset. The plot scale was transformed to a log10 scale. PRAD: Prostate adenocarcinoma; ACC: Adrenocortical carcinoma; UVM: Uveal Melanoma; Lines represent the linear regression analysis; r is the Spearman correlation coefficient, p-values indicate statistical significance of positive correlation according to Spearman