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Fig. 5 | Molecular Cancer

Fig. 5

From: Circular RNA circSDHC serves as a sponge for miR-127-3p to promote the proliferation and metastasis of renal cell carcinoma via the CDKN3/E2F1 axis

Fig. 5

circSDHC regulates CDKN3/E2F1 and promotes RCC progression by the sponge effect towards miR-127-3p. a. Cell migration and invasion abilities of 786-O transfected with control vector, circSDHC siRNA alone or circSDHC siRNA plus miR-127-3p inhibitor. b. Cell migration and invasion abilities of 769P transfected with control vector, circSDHC overexpression plasmid alone or circSDHC overexpression plasmid plus miR-127-3p mimics. c. Cell proliferation ability of 786-O transfected with control vector, circSDHC siRNA alone or circSDHC siRNA plus miR-127-3p inhibitor. d. Cell proliferation ability of 769P transfected with control vector, circSDHC overexpression plasmid alone or circSDHC overexpression plasmid plus miR-127-3p mimics. e. Western blot of CDKN3 and E2F1 levels after 786-O transfected with control vector, circSDHC siRNA alone or circSDHC siRNA plus miR-127-3p inhibitor. f. Western blot of CDKN3 and E2F1 levels after 786-O transfected with control vector, circSDHC overexpression plasmid alone or circSDHC overexpression plasmid plus miR-127-3p mimics

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Molecular Cancer

ISSN: 1476-4598