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Fig. 9 | Molecular Cancer

Fig. 9

From: CircWAC induces chemotherapeutic resistance in triple-negative breast cancer by targeting miR-142, upregulating WWP1 and activating the PI3K/AKT pathway

Fig. 9

Inhibition of circWAC can increase chemosensitivity to PTX in vivo. a Image of representative resected tumors from four groups of xenografted nude mice on the 36th day. b Tumor volumes were monitored during the 36-d time course. c The expression levels of circWAC, miR-142 and WWP1 in tumor tissues were determined by qRT-PCR. d The levels of WWP1 and pS473-AKT in tumor tissues were detected by Western blotting. e H&E staining was performed to evaluate tissue morphology, and IHC was performed to visualize WWP1 and pS473-AKT. *P < 0.05, **P < 0.01, ***P < 0.001

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Molecular Cancer

ISSN: 1476-4598