Fig. 1
Frequent downregulation of FBW7 in human epithelial ovarian cancer. a Expression of FBW7 in cancerous and normal ovarian tissues detected by IB. b Expression of FBW7 in cancerous and normal ovarian tissues analyzed by RT-qPCR. c-d Expression of FBW7 by IHC staining of human ovarian cancer tissue arrays. Scale bar, 200 μm. e FBW7 downregulation is significantly associated with shorter overall survival in epithelial ovarian cancer patients. f No significant correlation is observed between FBW7 expression and progression-free survival. g Quantification of m6A levels in 13 normal ovarian specimens and 60 ovarian cancer tissues classified into FBW7 high expression and low expression groups. h Higher level of m6A levels is significantly associated with better overall survival in epithelial ovarian cancer patients. m6A high: m6A ≥ 1.04%, m6A low: m6A < 1.04%. Results were presented as mean ± SD of three independent experiments. *P < 0.05 or **P < 0.01 indicates a significant difference between the indicated groups