Fig. 2

Overexpression of FBW7 significantly suppresses ovarian cancer cell proliferation and growth in vitro and in vivo. a Stable overexpression of FBW7 in SKOV3 and OVCAR429 cells. The expression of FBW7 is verified at both mRNA and protein levels. b Overexpression of FBW7 significantly reduces the proliferation rate of SKOV3 and OVCAR429 cells. c Overexpression of FBW7 impairs the colony-forming ability of ovarian cancer cells. d Overexpression of FBW7 suppresses anchorage-independent growth ovarian cancer cells. e Overexpression of FBW7 promotes ovarian cancer cell apoptosis. f Overexpression of FBW7 in SKOV3 cells markedly suppresses ovarian tumor growth in the xenograft mice. g The size of tumors formed in the xenograft mice is monitored every 3 days. h Overexpression of FBW7 significantly reduces weight of tumors in the xenograft mice. Results were presented as mean ± SD of three independent experiments. *P < 0.05 or **P < 0.01 indicates a significant difference between the indicated groups