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Fig. 8 | Molecular Cancer

Fig. 8

From: A novel protein encoded by circMAPK1 inhibits progression of gastric cancer by suppressing activation of MAPK signaling

Fig. 8

MAPK1–109aa play a tumor suppressor role merely through the MAPK pathway. a After adding shcircMAPK1 NC, MEK1 inhibitor (PD0325901), shcircMAPK1 plus PD0325901 to 7901 and 803 cell lines, the expression levels of MAPK1–109aa and downstream cytokines in the MAPK pathway. b Colony formation assay was performed to detect proliferation ability of cells mentioned above. C The number of cells is counted with image J. d EdU assay was performed to detect proliferation ability of cells mentioned above. Scale bar: 100 μm. e The number of cells is counted with image J. f Left panel: The effect of addition mentioned above on cell migration was examined by Transwell assay. Scale bar: 100 μm. Right panel: Quantitative of the cells by image J. Graph represents mean ± SD; *p < 0.05, **p < 0.01, and ***p < 0.001

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Molecular Cancer

ISSN: 1476-4598