Table 1 Role of sEVs cargo in initiation and progression of GC

protein

CD97

SGC-7901

SGC-7901

Promote cell proliferation and invasion

[45]

protein

FZD10

HGC-27 and N-87

HGC-27 and N-87

Sustain cancer cell proliferation

[53]

protein

UBR2

p53^−/−mBMMSC

p53^+/+ mBMMSC and MFC

Promote cell proliferation, migration, and stemness

[54]

protein

GKN1

HFE-145

AGS and MKN1

Inhibit gastric tumorigenesis

[55]

protein

TRIM3

Overexpressed MGC-803 and SGC-7901

MGC-803 and SGC-7901

Suppress GC growth

[56]

miRNA

miR-15b-3p

SGC-7901 and BGC-823

SGC-7901 and BGC-823

Enhance tumorigenesis and malignant transformation

[57]

miRNA

miR-221

GC-MSCs

HGC-27

Promote cell proliferation and migration

[58]

miRNA

miR-221

BM-MSCs

BGC-823 and SGC-7901

Enhance cell proliferation, migration, invasion, and adhesion to the matrix

[59]

miRNA

miR-1290

SGC-7901 and AGS

SGC-7901 and AGS

Promote proliferation and invasion

[60]

miRNA

miR-423-5p

SGC-7901 and HGC-27

SGC-7901 and HGC-27

Promote cancer growth

[61]

miRNA

miR-155-5p

GES-1 and AGS

AGS

Promote proliferation and migration

[62]

miRNA

miR-301a-3p

Hypoxia MGC803

MGC803 and MKN45

Promote GC progression

[63]

lncRNA

SPRY4-IT1

BGC-823

MKN-28

Promote cell growth

[64]

lncRNA

ZFAS1

BGC-823 and MGC-803

MKN-28

Enhance cell proliferation and migration

[65]

lncRNA

lncHEIH

HGC-27

GES-1

Promote GC progression

[66]

lncRNA

lnc01559

MSCs

HGC-27 and AGS

Promote GC progression

[67]

circRNA

circNRIP1

BGC-823 and MKN-45

BGC-823 and MKN-45

Promote GC progression

[68]

circRNA

circSHKBP1

BGC-823 and HGC-27

BGC-823 and HCG-27

Promote GC progression

[69]

circRNA

circNHSL1

HGC-27 and AGS

HGC-27 and AGS

Contributes to GC progression

[70]