From: The role and application of small extracellular vesicles in gastric cancer
Type | Contents | Donor cells | Recipient cells | Function | Ref. |
---|---|---|---|---|---|
protein | TRIM3 | Overexpressed MGC-803 and SGC-7901 | MGC-803 and SGC-7901 | Suppress GC metastasis | [56] |
protein | YB-1 | SGC-7901 | HUVECs | Promote angiogenesis | [76] |
protein | EGFR | SGC-7901 | Liver cells | Promote GC liver metastasis | [77] |
protein | Wnt5a | LNM-derived GC cells | BM-MSCs | maintaining tumour-promoting phenotype and function | [78] |
miRNA | miR-130a | SGC-7901 | HUVECs | Promote angiogenesis and tumour growth | [79] |
miRNA | miR-135b | SGC-7901 | HUVECs | Promote angiogenesis | [80] |
miRNA | miR-155 | SGC-7901 | HUVECs | Promote growth, metastasis, and tube formation of vascular cells | |
miRNA | miR-23a | HGC-27 | HUVECs | Promote angiogenesis | [83] |
miRNA | miR-6785-5p | HUVECs | MGC-803 and SGC-7901 | Suppress angiogenesis and metastasis | [84] |
miRNA | miR-196a-1 | GSU and N-87 | GSU and N-87 | Promote GC cell invasion and metastasis | [85] |
miRNA | GKN1 | HFE-145 | AGS and MKN1 | Suppress migration and invasion of GC cells by inhibiting epithelial-mesenchymal transition. | [71] |
miRNA | miR-29 | Peritoneal fluid | / | Suppress growth of disseminated peritoneal tumour cells | [86] |
miRNA | miR-21-5p | MGC-803, MKN-45, HGC- 27, and SGC-7901 | PMC and HMrSV5 | Induce MMT and promote tumour peritoneal metastasis | [87] |
miRNA | miR-423-5p | Overexpressed SGC-7901 and HGC-27 | SGC-7901 and HGC-27 | Promote GC metastasis | [61] |
miRNA | miR-301a-3p | Hypoxia MGC803 | MGC803 and MKN45 | Promote GC metastasis | [63] |
lncRNA | PCGEM1 | HGC | NGC | Promote invasive and metastasis | [88] |
ncRNA | X26nt | MGC-803 | HUVECs | Increases angiogenesis and vascular permeability | [89] |
circRNA | circ-RanGAP1 | HGC-27 and AGS | HGC-27 and AGS | Promote GC invasion and metastasis | [90] |