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Fig. 7 | Molecular Cancer

Fig. 7

From: The circular RNA circSPARC enhances the migration and proliferation of colorectal cancer by regulating the JAK/STAT pathway

Fig. 7

circSPARC intensified the nuclear translocation of STAT3 in CRC via recruiting FUS. A and B. ChIRP and RIP assay were conducted to prove the interaction between circSPARC and FUS in HCT116 and DLD1 cells. C. Western blot assay verified the effect of circSPARC on FUS protein in CRC cells. D. The interaction between FUS and STAT3 was confirmed by coIP assay. E. Western blot assay was applied to detect the level of STAT3 after nuclear-cytoplasm separation in DLD1 cell. F. The co-localization of circSPARC and FUS, as well as that of FUS and STAT3, was validated by IF analysis. *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001

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Molecular Cancer

ISSN: 1476-4598