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Fig. 8 | Molecular Cancer

Fig. 8

From: The circular RNA circSPARC enhances the migration and proliferation of colorectal cancer by regulating the JAK/STAT pathway

Fig. 8

CircSPARC enhances tumour growth and metastasis in vivo. A-C. HCT116 cells stably transfected with sh-circSPARC or vector were injected subcutaneously into the BALB/c nude mice. Tumour volume and weight were dramatically decreased in sh-circSPARC group. D. H & E staining was applied to identify the subcutaneous tumours. E. The expression of JAK2 in tumours were analysed by western blot assay. N: sh-NC group. S: sh-circSPARC group. F. IHC assay demonstrated the level of JAK2 and Ki67 in pairs of tumours. G. After HCT116 cells with knockdown circSPARC injected into the tail vein of nude mice, in vivo fluorescence imaging, the gross lesion in lung tissues, H. E staining and the IHC of Ki67 of metastatic nodules in the lungs were observed. H. The hypothetical model depicts the roles of circSPARC in the promotion of CRC. *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001

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Molecular Cancer

ISSN: 1476-4598