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Fig. 3 | Molecular Cancer

Fig. 3

From: CHEK1 and circCHEK1_246aa evoke chromosomal instability and induce bone lesion formation in multiple myeloma

Fig. 3

CHEK1 evokes chromosomal instability (CIN) in MM. A–B Giemsa staining revealed that CHEK1 OE increased the separation error rate and number of multi-nuclear cells in (A) ARP1 and (B) H929 cells. C–D Increased chromosomal plate width and decreased mitotic bipolar spindle length in CHEK1-OE ARP1 and H929 cells relative to WT, as demonstrated by immunofluorescent (IF) staining for α-tubulin and DAPI. E A comparative genomic hybridization (CGH) array revealed significant gains and losses of multiple chromosomal segments in CHEK1-OE ARP1 and H929 cells relative to WT. F In WT and CHEK1-OE cells treated with vehicle or Borbezomib, chromosomal plate width was highest and mitotic spindle length lowest in the Borbezomib-treated CHEK1-OE group

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Molecular Cancer

ISSN: 1476-4598