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Fig. 4 | Molecular Cancer

Fig. 4

From: Small extrachromosomal circular DNA (eccDNA): major functions in evolution and cancer

Fig. 4

Diversity of eccDNA and its roles in evolution. A Structural diversity of eccDNA. Different types of eccDNA have different genetic contents, which constitute the eccDNA structural diversity. B Functional diversity of eccDNA. The eccDNA structural diversity and unique topological structure contribute to the multiple functions of eccDNA by potentially driving the expression of coding RNAs, noncoding RNAs, and other RNAs. C Numerical diversity of eccDNA as well as the role and mechanism of eccDNA in evolution (modified based on Verhaak et al. [71]). Cells with eccDNA functional diversity formed from different pathways triggered by exogenous stimuli have an enhanced opportunity to generate eccDNA numerical diversity, which is attributed to cell survival advantages in environmental adaptation and evolution. The cycle number represents the copy number of eccDNA

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