Fig. 1

Overview of m6A modification. m⁶A modification is installed by the multicomponent m⁶A methyltransferases complex (writers) and removed by demethylases (erasers). The m⁶A modification is then identified by m⁶A readers which determine the fate of these RNAs and involved in various cellular processes. In the nucleus, m⁶A are identified by nuclear readers and modulates RNA transcription (transcription activation and termination), splicing (mRNAs, miRNAs, lncRNAs and circRNAs maturing) and structure (influence readers binding and splicing). Mature RNAs modified by m⁶A in the nucleus are recognized by readers, which subsequently mediate subcellular localization. In the cytoplasm, m⁶A are identified by cytoplasmic readers and modulates RNA stability (enhance stability or facilitate degradation), translation (promote translation via multiple mechanisms), and binding capacity (RNA-RBP interaction and RNA-RNA interaction)