Table 2 Crosstalk between m⁶A and circRNAs

m⁶A regulates circRNAs expression

circMETTL3

METTL3 facilitates circMETTL3 expression in an m⁶A-dependent manner

[97]

circ1662

METTL3 induced circ1662 generation by binding its flanking sequences and installing m⁶A modifications

[98]

circCUX1

METTL3 mediates the m⁶A methylation of circCUX1 and stabilizes circCUX1

[99]

circRNA-SORE

m⁶A modification raises circRNA-SORE level by increasing RNA stability

[100]

circRNAs

m⁶A modification cause circRNAs selectively degraded by RNase P/MRP complex

[101]

m⁶A regulates circRNAs distribution

circGFRα1

METTL14 promotes cytoplasmic export of m⁶A-modified circGFRα1 through the GGACU motif

[102]

circNSUN2

m⁶A modification of circNSUN2 facilitates cytoplasmic export

[60]

m⁶A regulates circRNAs function

circRNAs

Extensive m⁶A modifications in circRNAs drives protein translation in a cap-independent fashion

[87]

circRNAs

m⁶A modification controls circRNA immunity

[103]

circRNAs regulate m⁶A

hsa_circ_0072309

hsa_circ_0072309 upregulates the expression of m⁶A demethylase FTO by targeting miR-607

[104]

circMAP2K4

circMAP2K4 promote YTHDF1 expression by binding with hsa-miR-139-5p

[105]

circRAB11FIP1

circRAB11FIP1 regulated the m⁶A methylation of ATG5 and ATG7 mRNA via upregulating FTO

[106]

circMEG3

circMEG3 inhibits the expression of METTL3 dependent on HULC

[107]

circNOTCH1

circNOTCH1 regulates the m⁶A modification on Nothch1 mRNA by binding to METTL14.

[108]

circZbtb20

circZbtb20 enhances the interaction of ALKBH5 with Nr4a1 mRNA, leading to ablation of the m⁶A on Nr4a1 mRNA

[109]

circSTAG1

circSTAG1 regulates m⁶A modification on FAAH by mediating ALKBH5 translocation

[110]