Table 2 Dysregulated circRNAs in cancer

CircMEMO1

hepatocellular carcinoma(HCC)

As a sponge for miR-106b-5p

Inhibit cancer cell proliferation, migration and invasion and increase the sensitivity of HCC cells to sorafenib treatment.

[46]

CircMALAT1

hepatocellular carcinoma

Acts as mRNA translation brake and miR-6887-3p sponge

Promote the self-renewal of hepatocellular carcinoma stem cells

[47]

CircIGHG

oral squamous cell carcinoma

Acts as miR-142-5p sponge

Promote cancer cell invasiveness

[48]

CircMRPS35

gastric cancer

Acts as a modular scaffold to recruit histone acetyltransferase KAT7

Inhibit the proliferation and invasion of cancer cells

[49]

CircACTN4

breast cancer

Binding far upstream element binding protein 1

Promotes cancer cell proliferation, invasion and migration

[50]

CircSKA3

breast cancer

Binds integrin β1 to induce Invadopodium formation

Promote cancer cell migration and invasion

[51]

CircNTRK2

Esophageal cancer

Acts as a sponge for miR-140-3p

Promotes cancer cell proliferation, invasion and migration

[52]

CircNDUFB2

non-small cell lung cancer (NSCLC)

As a scaffold to enhance the interaction between TRIM25 and IGF2BPs

A suppressor in the progression of NSCLC

[53]

CircSDHC

renal cell carcinoma(RCC)

Serves as a sponge for miR-127-3p

promotes RCC proliferation and aggression

[54]

CircPTPRA

bladder cancer

Interacting with IGF2BP1

A tumor suppresso

[55]

CircZFR

cervical cancer

Bounding with SSBP1 to promote the assembly of CDK2/cyclin E1 complexes

Promotes cancer cell proliferation, invasion and migration

[55]

Circ2082

glioblastoma

Binds to RMB3 and is part of the nuclear DICER complex

Reduce the tumorigenicity of glioblastoma cells

[56]

CircECE1

osteosarcoma

Interacts with c-Myc to prevent speckle-type POZ-mediated c-Myc ubiquitination and degradation

Inhibit cancer cell proliferation and metastasis

[57]

CircBFAR

Pancreatic cancer

Sponge miR-34b-5p up-regulates the expression of mesenchymal-epithelial transition factor

Promotes cancer cell proliferation, invasion and migration

[58]

CircSPARC

Colorectal cancer

Sponge miR-485-3p to upregulate JAK2 expression

Enhances tumour growth and metastasis

[59]

Circ_0020710

melanoma

Sponge miR-370-3p to up-regulate the expression of CXCL12

Promotes cancer cell proliferation, invasion and migration

[60]

CircCRIM1

nasopharyngeal carcinoma

Sponge miR-422a to block the suppression effect of miR-422a on FOXQ1

Promote cancer cell migration and invasion

[61]

CircTNPO3

Ovarian Cancer

Sponge miR-1299 to up-regulate NEK2 expression

Enhance the resistance of ovarian cancer cells to PTX

[62]

Circ_0002577

endometrial cancer

Acts as a miR-625-5p sponge, upregulating IGF1R and activating the PI3K/Akt pathway

Promotes cancer cell proliferation, invasion and migration

[63]