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Table 2 Dysregulated circRNAs in cancer

From: Circular RNAs’ cap-independent translation protein and its roles in carcinomas

CircRNA Cancer type Mechanism Biological function Ref
CircMEMO1 hepatocellular carcinoma(HCC) As a sponge for miR-106b-5p Inhibit cancer cell proliferation, migration and invasion and increase the sensitivity of HCC cells to sorafenib treatment. [46]
CircMALAT1 hepatocellular carcinoma Acts as mRNA translation brake and miR-6887-3p sponge Promote the self-renewal of hepatocellular carcinoma stem cells [47]
CircIGHG oral squamous cell carcinoma Acts as miR-142-5p sponge Promote cancer cell invasiveness [48]
CircMRPS35 gastric cancer Acts as a modular scaffold to recruit histone acetyltransferase KAT7 Inhibit the proliferation and invasion of cancer cells [49]
CircACTN4 breast cancer Binding far upstream element binding protein 1 Promotes cancer cell proliferation, invasion and migration [50]
CircSKA3 breast cancer Binds integrin β1 to induce Invadopodium formation Promote cancer cell migration and invasion [51]
CircNTRK2 Esophageal cancer Acts as a sponge for miR-140-3p Promotes cancer cell proliferation, invasion and migration [52]
CircNDUFB2 non-small cell lung cancer (NSCLC) As a scaffold to enhance the interaction between TRIM25 and IGF2BPs A suppressor in the progression of NSCLC [53]
CircSDHC renal cell carcinoma(RCC) Serves as a sponge for miR-127-3p promotes RCC proliferation and aggression [54]
CircPTPRA bladder cancer Interacting with IGF2BP1 A tumor suppresso [55]
CircZFR cervical cancer Bounding with SSBP1 to promote the assembly of CDK2/cyclin E1 complexes Promotes cancer cell proliferation, invasion and migration [55]
Circ2082 glioblastoma Binds to RMB3 and is part of the nuclear DICER complex Reduce the tumorigenicity of glioblastoma cells [56]
CircECE1 osteosarcoma Interacts with c-Myc to prevent speckle-type POZ-mediated c-Myc ubiquitination and degradation Inhibit cancer cell proliferation and metastasis [57]
CircBFAR Pancreatic cancer Sponge miR-34b-5p up-regulates the expression of mesenchymal-epithelial transition factor Promotes cancer cell proliferation, invasion and migration [58]
CircSPARC Colorectal cancer Sponge miR-485-3p to upregulate JAK2 expression Enhances tumour growth and metastasis [59]
Circ_0020710 melanoma Sponge miR-370-3p to up-regulate the expression of CXCL12 Promotes cancer cell proliferation, invasion and migration [60]
CircCRIM1 nasopharyngeal carcinoma Sponge miR-422a to block the suppression effect of miR-422a on FOXQ1 Promote cancer cell migration and invasion [61]
CircTNPO3 Ovarian Cancer Sponge miR-1299 to up-regulate NEK2 expression Enhance the resistance of ovarian cancer cells to PTX [62]
Circ_0002577 endometrial cancer Acts as a miR-625-5p sponge, upregulating IGF1R and activating the PI3K/Akt pathway Promotes cancer cell proliferation, invasion and migration [63]