Table 2 Single-agent therapies in clinical trials
From: Role of oncogenic KRAS in the prognosis, diagnosis and treatment of colorectal cancer
Inhibitor | Biomarker | Cancer type | CRC patients enrollment | Phase | NCT number | Status |
|---|---|---|---|---|---|---|
KRASG12C inhibitors | ||||||
AMG 510 | KRASG12C mutation | Advanced solid tumors | Enrolled | I/II | NCT03600883 | Recruiting |
MRTX849 | KRASG12C mutation | Advanced solid tumors | Enrolled | I/II | NCT03785249 | Recruiting |
JNJ-74699157 | KRASG12C mutation | Advanced solid tumors | Enrolled | I | NCT04006301 | Completed |
LY3499446 | KRASG12C mutation | Advanced solid tumors | Enrolled | I/II | NCT04165031 | Terminated |
SOS inhibitors | ||||||
BI 1701963 | KRAS mutations | Advanced solid tumors | Not mentioned | I | NCT04111458 | Recruiting |
SHP2 inhibitors | ||||||
RMC-4630 | Mutations that hyperactive the RAS-MAPK pathway | Relapsed or refractory solid tumors | Not mentioned | I | NCT03634982 | Recruiting |
RAF inhibitors | ||||||
LY3009120 | BRAF, NRAS or KRAS mutations | Advanced or metastatic solid tumors | Enrolled | I | NCT02014116 | Terminated |
BGB-283 | BRAF, NRAS or KRAS mutations | Advanced solid tumors | Enrolled | I | NCT02610361 | Completed |
ERK inhibitors | ||||||
GDC-0994 | BRAF or KRAS mutations | Advanced or metastatic solid tumors | Enrolled | I | NCT01875705 | Completed |
BVD-523 | NRAS, HRAS, KRAS, BRAF, MEK or ERK mutations | Advanced MAPK pathway-altered malignancies | Enrolled | I | NCT04566393 | Available |
Adoptive cell therapies | ||||||
Anti-KRAS G12D mTCR | HLA-A*11:01 positive KRASG12D mutation | Advanced solid tumors | Enrolled | I/II | NCT03745326 | Suspended |
Anti-KRAS G12V mTCR | HLA-A*11:01 positive KRASG12D mutation | Advanced solid tumors | Enrolled | I/II | NCT03190941 | Suspended |
Cancer vaccines | ||||||
TG02 | KRAS exon 2, codon 12 or 13 mutation | Rectal cancer | Enrolled | I | NCT02933944 | Terminated |
mRNA-5671 | KRASG12D, KRASG12V, KRASG12C, KRASG13D mutation | NSCLC, non-MSI-H CRC, PDAC | Enrolled | I | NCT03948763 | Recruiting |