Table 1 CircRNAs in acute myeloid leukemia. ↑ Indicate increased expression, ↓ Indicate decreased expression. BM (Bone marrow). Ref. (References)
CircRNA Circ based ID (Common Name) | Host gene | Sample (Expression pattern) | Method | Target miRNA/Target gene | Function | Ref. |
|---|---|---|---|---|---|---|
Circ-VIM | Vimentin | BM (↑) | qRT-PCR |  | Diagnostic/prognostic biomarker | [32] |
Circ-FOXO3 | FOXO3 | BM (↓) | qRT-PCR |  | Diagnostic biomarker | [33] |
Hsa_circ_0004277 | WDR37 | BM (↓) | Microarray/qRT-PCR |  | Diagnostic marker, dynamic marker with disease status | [34] |
Circ_0009910 | MFN2 | BM (↑) | Microarray/qRT-PCR | miR-20a-5p | Prognostic marker | [35] |
Hsa_circ_101141 (Circ-ANAPC7) | ANAPC7 | BM (↑) | Microarray/qRT-PCR |  |  | [36] |
Hsa_circ_104700/Hsa_circ_0005273 (Circ-PTK2) |  | BM (↑) | qRT/PCR | miR-330-5p/FOXM1 | Prognostic marker | [37] |
Hsa_circ_0100181 (CircPAN3) | PAN3 | BM (↑) | Microarray/qRT-PCR | miR-153-5p, miR-183-5p/XIAP | Chemoresistance | |
Hsa_circ_0035559 (Circ-ANXA2) | ANXA2 | BM (↑) | Microarray/qRT-PCR | miR-23a-5p and miR-503-3p | Prognostic biomarker/ Chemoresistance | [59] |
Hsa_circ_0000488 (Cir-DLEU2) | DLEU2 | BM (↑) | Microarray | miR-496/PRKACB | Cell proliferation and inhibition of apoptosis | [41] |
Circ_0000370 | FLI-1 | Blood (↑) | Microarray | miR-1299/S100A7A | Oncogene | [44] |
Hsa_circ_0006332 (CircMYBL2) | MYBL2 | (↑) |  | FLT3 translation regulation through PTPB1 | Oncogene Therapeutic potential | [45] |
Hsa_circ_0075001 | NPM1 | BM (↑) | Microarray |  | Downregulation of Toll-like receptor signaling | [54] |
Hsa_circ_0004136 |  | BM (↑) | Microarray/qRT-PCR | miR-142 and miR-29a | Cell proliferation | [48] |
Hsa_circ_0001346 (circRNF13) | RNF13 | Blood (↑) | qRTPCR | miR-1224-5p | Cell proliferation and migration | [49] |
Hsa_circ_0121582 | GSK3beta | BM (↓) | High-throughput sequencing/qRTPCR | miR-224/GSK3beta | Inhibition of proliferation in AML cells | [50] |
Hsa_circ_100,290 | SLC30A7 | BM (↑) | qRTPCR | Mir-203/Rab10 | Regulation of proliferation and apoptosis | [51] |
Hsa_circ_0079480 | ISPD | BM (↑) | qRT-PCR | miR-655-3p/HDGF | Regulation of proliferation and apoptosis | [53] |
Hsa_circ_0002483 |  | BM (↑) | qRT-PCR | miR-758-3p/MYC | Regulation of proliferation, cell-cycle progression, and apoptosis | [52] |