Cancer cell-derived exosomal circUSP7 induces CD8+ T cell dysfunction and anti-PD1 resistance by regulating the miR-934/SHP2 axis in NSCLC

Table 2 Univariate and Multivariate Analyses of Factors Associated with Overall Survival

Factors	OS
	Multivariate
	Univariate p	HR	95%CI	P value
Sex (Female vs. Male)	0.645			NA
Age (years) (≤60 vs. > 60)	0.447			NA
Smoking status (Smokers vs. Nonsmokers)	0.896			NA
Histological type (SCC vs. Adenocarcinomas)	0.580			NA
Lymph node metastasis (Yes vs. No)	0.001	0.405	0.232–0.706	0.024
Differentiation (Well and moderate vs. Poor)	0.053			NS
Tumor size (diameter, cm) (> 3 vs. ≤3)	0.038			NS
TNM (III-IV vs. I-II)	0.276			NA
CircUSP7 expression (High vs. Low)	0.001	3.090	1.552–6.151	0.037

OS Overall survival, NA Not adopted, NS Not significantly, SCC Squamous cell carcinoma, 95%CI 95% confidence interval, HR Hazard ratio; Cox proportional hazards regression model

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